Endocrine Abstracts

Context: Glucocorticoids have adverse systemic effects which may predispose to cardiovascular disease. The effect of glucocorticoid use on cardiovascular disease has not been assessed.Objective: To test the hypothesis that users of exogenous glucocorticoids have a dose-dependent increased risk of cardiovascular disease; in particular, that supraphysiological doses will be associated with cardiovascular disease.Design: A cohort study using a record linkage database....

Objective: To describe the mortality and vascular morbidity in patients after treatment for hyperthyroidism and hypothyroidism.Method: We constructed an electronic database using record linkage of a community thyroid follow-up register, radioiodine database, regional biochemistry, regional prescribing database, hospital admissions and regional death certification. This was made possible by a unique patient identifier used locally for all healthcare episo...

Background: The objective of this study was to define the incidence and prevalence of treated thyroid dysfunction in a complete and representative population base.Method: We used record-linkage technology to retrospectively identify subjects treated for hyperthyroidism or hypothyroidism in the general population of Tayside, Scotland from 1 January 1993 to 30 April 1997. Thyroid status was ascertained by record-linkage of patient-level datasets containing...

Background: Glucocorticoid (GC) therapy is standard of care of management of Duchenne Muscular Dystrophy (DMD) but its use is associated with a range of side-effects. Weight gain leading to significant obesity is common in GC-treated boys.Aim(s): To evaluate changes in growth parameters: height-SDS, weight-SDS, body mass index (BMI)-SDS following initiation of GC in DMD.Methods: Between 2013-2019, 26 boys with DMD were commenced on...